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Journal Articles NPJ Microgravity Year : 2023

How do gravity alterations affect animal and human systems at a cellular/tissue level?

1 UniFI - Università degli Studi di Firenze = University of Florence = Université de Florence
2 Ohio University
3 SSSUP - Scuola Universitaria Superiore Sant'Anna [Pisa]
4 SCK-CEN - Centre d'Etude de l'Energie Nucléaire
5 I-STEM - Institut des cellules souches pour le traitement et l'étude des maladies monogéniques
6 Goethe University Frankfurt
7 UNIMI - Università degli Studi di Milano = University of Milan
8 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
9 CNR - National Research Council of Italy | Consiglio Nazionale delle Ricerche
10 EPHE - École Pratique des Hautes Études
11 UNIPV - Università degli Studi di Pavia = University of Pavia
12 UNISI - Università degli Studi di Siena = University of Siena
13 UNIBA - Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro
14 SIMPA - Stress, Immunité, Pathogènes
15 TU Dresden - Technische Universität Dresden = Dresden University of Technology
16 OVGU - Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg]
17 Aarhus University [Aarhus]
18 SAINBIOSE - Santé Ingénierie Biologie Saint-Etienne
19 ESA - Agence Spatiale Européenne = European Space Agency
20 CSIC - Consejo Superior de Investigaciones Cientificas [España] = Spanish National Research Council [Spain]
21 DLR - German Aerospace Center
22 ULB - Université libre de Bruxelles
23 Aristotle University of Thessaloniki
24 Amsterdam UMC - Amsterdam University Medical Center
25 University Medical Center [Utrecht]
26 IFREMER - Institut Français de Recherche pour l'Exploitation de la Mer
27 MVP - Max Von Pettenkofer Institute
28 TU Wien - Vienna University of Technology = Technische Universität Wien
29 BMLS - Buchmann Institute for Molecular Life Sciences [Frankfurt am Main]
30 GSBMS - Groupement scientifique de Biologie et de Medecine Spatiale
31 EVOLSAN - Évolution et Santé Orale
32 UMR MARBEC - MARine Biodiversity Exploitation and Conservation - MARBEC
33 DLR Institute of Aerospace Medicine
34 University of Bristol [Bristol]
35 University of Pisa - Università di Pisa
36 ISS - Istituto Superiore di Sanità = National Institute of Health
37 DLR - Deutsches Zentrum für Luft- und Raumfahrt [Köln]
38 IRCCS San Raffaele Pisana - Istituto di Ricovero e Cura a Carattere Scientifico
39 Ospedale Policlinico San Martino [Genoa]
40 UniGe - Università degli studi di Genova = University of Genoa
41 VUB - Vrije Universiteit Brussel [Bruxelles]
Austin Brown
  • Function : Author
Cory Baumann
  • Function : Author
Sarah Baatout
Gianni Ciofani
Giuseppe Coppola
  • Function : Author
Jean-Pol Frippiat
Giada Genchi
  • Function : Author
Christine Hellweg
Elizabeth Pavezlorie
  • Function : Author
Petra Rettberg
Kevin Tabury
Christiane Thielemann
Ronnie Willaert
Nathaniel Szewczyk


Abstract The present white paper concerns the indications and recommendations of the SciSpacE Science Community to make progress in filling the gaps of knowledge that prevent us from answering the question: “How Do Gravity Alterations Affect Animal and Human Systems at a Cellular/Tissue Level?” This is one of the five major scientific issues of the ESA roadmap “Biology in Space and Analogue Environments”. Despite the many studies conducted so far on spaceflight adaptation mechanisms and related pathophysiological alterations observed in astronauts, we are not yet able to elaborate a synthetic integrated model of the many changes occurring at different system and functional levels. Consequently, it is difficult to develop credible models for predicting long-term consequences of human adaptation to the space environment, as well as to implement medical support plans for long-term missions and a strategy for preventing the possible health risks due to prolonged exposure to spaceflight beyond the low Earth orbit (LEO). The research activities suggested by the scientific community have the aim to overcome these problems by striving to connect biological and physiological aspects in a more holistic view of space adaptation effects.
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Dates and versions

hal-04264352 , version 1 (15-04-2024)





Francesca Cialdai, Austin Brown, Cory Baumann, Debora Angeloni, Sarah Baatout, et al.. How do gravity alterations affect animal and human systems at a cellular/tissue level?. NPJ Microgravity, 2023, 9 (1), pp.84. ⟨10.1038/s41526-023-00330-y⟩. ⟨hal-04264352⟩
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