Chemotherapy for Muscle-invasive Bladder Cancer: Impact of Cisplatin Delivery on Renal Function and Local Control Rate in the Randomized Phase III VESPER (GETUG-AFU V05) Trial - Centre François Baclesse Access content directly
Journal Articles Clinical Genitourinary Cancer Year : 2021

Chemotherapy for Muscle-invasive Bladder Cancer: Impact of Cisplatin Delivery on Renal Function and Local Control Rate in the Randomized Phase III VESPER (GETUG-AFU V05) Trial

1 AP-HP - Hopital Saint-Louis [AP-HP]
2 UNICANCER/CRLC - Centre Régional de Lutte contre le Cancer François Baclesse [Caen]
3 IPC - Institut Paoli-Calmettes
4 Département cancer environnement (Centre Léon Bérard - Lyon)
5 IUCT Oncopole - UMR 1037 - Institut Universitaire du Cancer de Toulouse - Oncopole
6 UNICANCER/CJP - Centre Jean Perrin [Clermont-Ferrand]
7 Département d'oncologie médicale [Rennes]
8 CRLCC - CRLCC Eugène Marquis
9 Institut de Cancérologie de la Loire Lucien Neuwirth
10 UNICANCER/ICO - Institut de Cancérologie de l'Ouest [Angers/Nantes]
11 UNICANCER/ICL - Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy]
12 CLCC Henri Becquerel - Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen
13 Hôpital Charles Nicolle [Rouen]
14 Institut Bergonié [Bordeaux]
15 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
16 Clinique Victor Hugo [Le Mans]
17 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
18 Groupe Hospitalier Diaconesses Croix Saint-Simon
19 CHU Henri Mondor [Créteil]
20 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
21 U981 - Biomarqueurs prédictifs et nouvelles stratégies moléculaires en thérapeutique anticancéreuse
22 Institut Jean Godinot [Reims]
23 SU - Sorbonne Université
24 Hôpital Cochin [AP-HP]
25 IRCM - U1194 Inserm - UM - Institut de Recherche en Cancérologie de Montpellier
26 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
27 CHU Pitié-Salpêtrière [AP-HP]
28 CHD Vendée - Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon
29 Institut Sainte Catherine [Avignon]
30 IMRB - Institut Mondor de Recherche Biomédicale
31 CIC Rouen - Centre d'Investigation Clinique [CHU Rouen]
Stéphane Culine
  • Function : Author
  • PersonId : 1110257
Gwenaelle Gravis
Hakim Mahammedi
  • Function : Author
  • PersonId : 1028435
Guilhem Roubaud
  • Function : Author
  • PersonId : 975634
Eric Voog
  • Function : Author
  • PersonId : 1033302
Carolina Saldana
Jean-Christophe Eymard
  • Function : Author
  • PersonId : 1123379
Jean-Philippe Spano
Mounira El Demery
  • Function : Author
Sabine Vieillot
  • Function : Author
Werner Hilgers
  • Function : Author
  • PersonId : 1099604
Yves Allory
Christian Pfister
  • Function : Author
  • PersonId : 1028438

Abstract

Background: Cisplatin-based combination chemotherapy before surgery is the standard of care for muscle-invasive bladder cancer. However, the optimal chemotherapy modalities have not been precisely defined to date.Patients and methods: In the VESPER trial, patients received after randomization either gemcitabine and cisplatin (GC, 4 cycles) or methotrexate, vinblastine, doxorubicin and cisplatin (dose dense [dd]-MVAC, 6 cycles). Creatinine clearance (CrCl) was calculated before each cycle according to the Cockroft and Gault formula. Definition criteria for local control after neoadjuvant chemotherapy included pathological complete response (ypT0N0), pathological downstaging (
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Dates and versions

hal-03625944 , version 1 (08-01-2024)

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Attribution - NonCommercial

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Stéphane Culine, Valentin Harter, Gwenaelle Gravis, Aude Fléchon, Christine Chevreau, et al.. Chemotherapy for Muscle-invasive Bladder Cancer: Impact of Cisplatin Delivery on Renal Function and Local Control Rate in the Randomized Phase III VESPER (GETUG-AFU V05) Trial. Clinical Genitourinary Cancer, 2021, 19 (6), pp.554-562. ⟨10.1016/j.clgc.2021.08.005⟩. ⟨hal-03625944⟩
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