Treatment strategies for thymic carcinoma in a real-life setting. Insights from the RYTHMIC network

Arthur Petat (1, 2) , Eric Dansin (3) , Fabien Calcagno (4) , Laurent Greillier (5, 6) , Eric Pichon (7) , Mallorie Kerjouan (8) , Christelle Clement-Duchene (9) , Bertrand Mennecier (10) , Virginie Westeel (11) , François Thillays (12) , Xavier Quantin (13) , Youssef Oulkhouir (14) , Luc Thiberville (15) , Charles Ricordel (8) , Vincent Thomas de Montpreville (16) , Lara Chalabreysse (1) , Véronique Hofman (17) , Thierry Molina (18) , Pierre Fournel (19) , Laurence Bigay Game (20) , Benjamin Besse (21) , Nicolas Girard (22)

1 HCL - Hospices Civils de Lyon
2 UCBL - Université Claude Bernard Lyon 1
3 UNICANCER/Lille - Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille]
4 Service d'Oncologie Médicale [CHRU Besançon]
5 COMPO - Méthodes computationnelles pour la prise en charge thérapeutique en oncologie : Optimisation des stratégies par modélisation mécaniste et statistique
6 Service d'oncologie multidisciplinaire innovations thérapeutiques [Hôpital Nord - APHM]
7 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
8 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
9 UNICANCER/ICL - Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy]
10 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
11 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
12 UNICANCER/ICO - Institut de Cancérologie de l'Ouest [Angers/Nantes]
13 IRCM - U1194 Inserm - UM - Institut de Recherche en Cancérologie de Montpellier
14 CHU Caen
15 CHU Rouen
16 CCML - Centre Chirurgical Marie Lannelongue
17 CHU - Hôpital Pasteur [Nice]
18 Département de Pathologie [CHU Necker]
19 Institut de Cancérologie de la Loire Lucien Neuwirth
20 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
21 Département de médecine oncologique [Gustave Roussy]
22 Institut Curie [Paris]

Thymic carcinomas are aggressive and difficult to treat a subset of thymic epithelial tumours that represent a heterogeneous group of rare intrathoracic malignancies. The treatment strategy of thymic carcinomas is based on whether surgical resection may be achieved, which represents the most significant favourable prognostic factor on survival. For this study, we took advantage of the unique prospective Réseau tumeurs THYMiques et Cancer (RYTHMIC) database to describe baseline characteristics, analyse treatment strategies in light of existing guidelines and provide landmark patient outcomes data with regards to response and survival of patients in a real-life clinical practice setting.

Mots clés: Chemotherapy; Guidelines; Radiotherapy; Surgery; Thymic carcinoma

Domaines: Cancer

Arthur Petat, Eric Dansin, Fabien Calcagno, Laurent Greillier, Eric Pichon, et al.. Treatment strategies for thymic carcinoma in a real-life setting. Insights from the RYTHMIC network. European Journal of Cancer, 2022, 162, pp.118-127. ⟨10.1016/j.ejca.2021.11.028⟩. ⟨hal-03524368⟩