Efficacy of CAR T-Cell Therapy is Not Impaired by Previous Bispecific Antibody Treatment in Large B-Cell Lymphoma.

Gilles Crochet (1) , Gloria Iacoboni (2) , Audrey Couturier (3) , Emmanuel Bachy (4) , Josu Iraola-Truchuelo (5) , Thomas Gastinne (6) , Guillaume Cartron (7) , Tom Fradon (8) , Bastien Lesne (8) , Mi Kwon (9) , Romain Gounot (10) , Nuria Martínez-Cibrian , Cristina Castilla-Llorente (11) , Pau Abrisqueta , Manuel Guerreiro , Clémentine Sarkozy (12) , Jose Maria Aspa-Cilleruelo , Vincent Camus (13) , Stéphanie Guidez (14) , Adrien Chauchet (15) , Eric Deconinck (15) , Krimo Bouabdallah (16) , Francesc Bosch (2) , Pere Barba (2) , Franck Morschhauser (17) , Houot Roch (3, 18)

1 UNamur - Université de Namur [Namur]
2 Vall d'Hebron University Hospital [Barcelona]
3 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
4 HCL - Hospices Civils de Lyon
5 UB - Universitat de Barcelona
6 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
7 CHU Montpellier = Montpellier University Hospital
8 LYSARC - The Lymphoma Academic Research Organisation [Lyon]
9 Hospital General Universitario "Gregorio Marañón" [Madrid]
10 Hôpital Henri Mondor
11 IGR - Institut Gustave Roussy
12 Institut Curie [Paris]
13 CLCC Henri Becquerel - Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen
14 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
15 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
16 CHU Pessac
17 GRITA - Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365
18 MOBIDIC - Microenvironment and B-cells: Immunopathology,Cell Differentiation, and Cancer

In this retrospective study, CAR T-cells remained effective in relapsed/refractory LBCL patients after prior exposure to bispecific antibodies (BsAbs) targeting different antigens. These results are relevant to clinical practice, particularly given the increasing use of BsAbs in earlier treatment lines.

Domaines: Cancer

Gilles Crochet, Gloria Iacoboni, Audrey Couturier, Emmanuel Bachy, Josu Iraola-Truchuelo, et al.. Efficacy of CAR T-Cell Therapy is Not Impaired by Previous Bispecific Antibody Treatment in Large B-Cell Lymphoma.. Blood, 2024, ⟨10.1182/blood.2024024526⟩. ⟨hal-04607118⟩