A. Bassuny-ismael, D. Sekkai, C. C. Bout, D. Mevelec, and M. , The MIC3 Gene of Toxoplasma gondii Is a Novel Potent Vaccine Candidate against Toxoplasmosis, Infection and Immunity, vol.71, issue.11, pp.6222-6228, 2003.
DOI : 10.1128/IAI.71.11.6222-6228.2003

P. Amouyel, Vers des profils pharmacogénétiques? Les nouvelles frontières de la génomique Towards pharmacogenetic profiles? Surprising genomics, Biofutur Puteaux, issue.206, pp.86-88, 2000.

R. Argnani, M. Lufino, M. Manservigi, R. Manservigi, C. Bagnis et al., Replication-competent herpes simplex vectors: design and applications, Gene Therapy, vol.73, issue.SUP1, pp.170-177, 2005.
DOI : 10.1006/exer.1999.0711

N. Aubrey, J. Muzard, J. Peter, H. Rochat, M. Goyffon et al., Engineering of a recombinant Fab from a neutralizing IgG directed against scorpion neurotoxin AahI, and functional evaluation versus other antibody fragments, Toxicon, vol.43, issue.3, pp.233-241, 2004.
DOI : 10.1016/j.toxicon.2003.11.024

S. Blanquet, R. Antonelli, L. Laforet, S. Denis, B. Marol et al., Living recombinant Saccharomyces cerevisiae secreting proteins or peptides as a new drug delivery system in the gut, Journal of Biotechnology, vol.110, issue.1, pp.37-49, 2004.
DOI : 10.1016/j.jbiotec.2004.01.012

S. Blanquet, B. Marol, E. Beyssac, D. Pompon, M. Renaud et al., The ???biodrug??? concept: an innovative approach to therapy, Trends in Biotechnology, vol.19, issue.10, pp.393-400, 2001.
DOI : 10.1016/S0167-7799(01)01739-5

F. Bouche, B. Marquet, Y. Yanagi, A. Steinmetz, and C. Muller, Neutralising immunogenicity of a polyepitope antigen expressed in a transgenic food plant: a novel antigen to protect against measles, Vaccine, vol.21, issue.17-18, pp.17-18, 2003.
DOI : 10.1016/S0264-410X(02)00747-8

P. Brodin, L. Majlessi, R. Brosch, D. Smith, G. Bancroft et al., Vaccine That Induces T Cell Immunity against Region of Difference 1 Antigens, The Journal of Infectious Diseases, vol.190, issue.1, pp.115-122, 2004.
DOI : 10.1086/421468

P. Bruheim, S. Borgos, P. Tsan, H. Sletta, T. Ellingsen et al., Chemical Diversity of Polyene Macrolides Produced by Streptomyces noursei ATCC 11455 and Recombinant Strain ERD44 with Genetically Altered Polyketide Synthase NysC, Antimicrobial Agents and Chemotherapy, vol.48, issue.11, pp.48-4120, 2004.
DOI : 10.1128/AAC.48.11.4120-4129.2004

I. Castagliuolo, E. Beggiao, P. Brun, L. Barzon, S. Goussard et al., Engineered E. coli delivers therapeutic genes to the colonic mucosa, Gene Therapy, vol.12, issue.14, pp.1070-1078, 2005.
DOI : 10.1038/sj.gt.3302574

M. Cazillis, V. Lelievre, and P. Gressens, Differenciation neurale des cellules souches embryonnaires Neural differentiation of murine embryonic stem cells ES, MS Medecine sciences, vol.21, issue.5, pp.484-490, 2005.

P. Chames and D. Baty, Antibody engineering and its applications in tumor targeting and intracellular immunization, FEMS Microbiology Letters, vol.189, issue.1, pp.1-8, 2000.
DOI : 10.1111/j.1574-6968.2000.tb09197.x

URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=

N. Chapal, M. Laplanche, G. Ribes, B. Pau, J. Garin et al., L'analyse pharmacoprotéomique: application de l'analyse protéomique à la découverte et au développement de nouvelles thérapeutiques: Du transcriptome au protéome, une nouvelle lecture de la cellule Pharmacoproteomics: application of proteomics for drug discovery and development: From transcriptome to proteome, a new lecture of the cell, Journal de la Societe de biologie, vol.196, issue.4, pp.317-322, 2002.

C. Chittimalla, L. Zammut, G. Zuber, and J. Behr, Monomolecular DNA Nanoparticles for Intravenous Delivery of Genes, Journal of the American Chemical Society, vol.127, issue.32, pp.11436-11441, 2005.
DOI : 10.1021/ja0522332

URL : https://hal.archives-ouvertes.fr/hal-00129832

A. Clergeot, P. Arnoux, and C. Lassale, Biomédicaments en France: Etat des lieux en 2004: Etude menée par les entreprises du médicament, 2004.

S. Cole, Comparative mycobacterial genomics as a tool for drug target and antigen discovery, European Respiratory Journal, vol.20, issue.Supplement 36, pp.78-86, 2002.
DOI : 10.1183/09031936.02.00400202

V. Colombie, C. Bideaux, G. Goma, and J. Uribelarrea, Effects of glucose limitation on biomass and spiramycin production by Streptomyces ambofaciens, Bioprocess and Biosystems Engineering, vol.65, issue.1, pp.55-61, 2005.
DOI : 10.1007/s00449-005-0015-2

P. Corvini, S. Delaunay, F. Maujean, E. Rondags, H. Vivier et al., Intracellular pH of Streptomyces pristinaespiralis is correlated to the sequential use of carbon sources during the pristinamycins-producing process, Enzyme and Microbial Technology, vol.34, issue.2, pp.101-107, 2004.
DOI : 10.1016/j.enzmictec.2003.06.002

S. Courtois, C. Cappellano, M. Ball, F. Francou, N. P. Helynck et al., Recombinant Environmental Libraries Provide Access to Microbial Diversity for Drug Discovery from Natural Products, Applied and Environmental Microbiology, vol.69, issue.1, pp.49-55, 2003.
DOI : 10.1128/AEM.69.1.49-55.2003

H. Daniell, S. Kumar, and N. Dufourmantel, Breakthrough in chloroplast genetic engineering of agronomically important crops, Trends in Biotechnology, vol.23, issue.5, pp.238-245, 2005.
DOI : 10.1016/j.tibtech.2005.03.008

D. Guerra, S. Bracci, C. Nilsson, K. Belcourt, A. Kessler et al., Entrapment of dispersed pancreatic islet cells in CultiSpher-S macroporous gelatin microcarriers: Preparation, in vitro characterization, and microencapsulation, Biotechnology and Bioengineering, vol.46, issue.6, pp.741-744, 2001.
DOI : 10.1002/bit.10053

L. Desigaux, C. Gourden, R. Bello, P. Richard, N. Oudrhiri et al., Nonionic Amphiphilic Block Copolymers Promote Gene Transfer to the Lung, Human Gene Therapy, vol.16, issue.7, pp.821-829, 2005.
DOI : 10.1089/hum.2005.16.821

D. Ianni, M. , D. Papa, B. , D. Ioanni et al., Interleukin 7-Engineered Stromal Cells: A New Approach for Hastening Naive T Cell Recruitment, Human Gene Therapy, vol.16, issue.6, pp.752-764, 2005.
DOI : 10.1089/hum.2005.16.752

S. Dincer, M. Turk, E. Piskin, C. Bagnis, O. Merten et al., Intelligent polymers as nonviral vectors, Gene Therapy, vol.96, issue.SUP1, pp.139-145, 2005.
DOI : 10.1016/S0304-4165(02)00202-7

S. Drouault, C. Juste, P. Marteau, R. P. Corthier, and G. , Oral Treatment with Lactococcus lactis Expressing Staphylococcus hyicus Lipase Enhances Lipid Digestion in Pigs with Induced Pancreatic Insufficiency, Applied and Environmental Microbiology, vol.68, issue.6, pp.3166-3168, 2002.
DOI : 10.1128/AEM.68.6.3166-3168.2002

A. Duffy, O. Dam, O. Bt, P. Strappe, C. Bagnis et al., Purification of adenovirus and adeno-associated virus: comparison of novel membrane-based technology to conventional techniques, Gene Therapy, vol.76, issue.SUP1, pp.62-72, 2005.
DOI : 10.1016/0042-6822(68)90122-0

J. Eidem, I. Rasmussen, E. Lunde, T. Gregers, A. Rees et al., Recombinant antibodies as carrier proteins for sub-unit vaccines: influence of mode of fusion on protein production and T-cell activation, Journal of Immunological Methods, vol.245, issue.1-2, pp.119-131, 2000.
DOI : 10.1016/S0022-1759(00)00274-X

I. Elbers, G. Stoopen, H. Bakker, L. Stevens, M. Bardor et al., Influence of Growth Conditions and Developmental Stage on N-Glycan Heterogeneity of Transgenic Immunoglobulin G and Endogenous Proteins in Tobacco Leaves, PLANT PHYSIOLOGY, vol.126, issue.3, pp.1314-1322, 2001.
DOI : 10.1104/pp.126.3.1314

P. England and P. Lafaye, Les anticorps appelés a la rescousse Le péril infectieux: quelles stratégies de lutte? Antibodies to the rescue, Biofutur Puteaux, vol.217, pp.78-81, 2001.

A. Epstein, C. Bagnis, O. Merten, and M. Mezzina, HSV-1-derived recombinant and amplicon vectors for preventive or therapeutic gene transfer: an overview, Gene Therapy, vol.12, issue.SUP1, p.153, 2005.
DOI : 10.1038/sj.gt.3302630

A. Epstein, P. Marconi, R. Argnani, and R. Manservigi, HSV-1-Derived Recombinant and Amplicon Vectors for Gene Transfer and Gene Therapy, Current Gene Therapy, vol.5, issue.5, pp.445-458, 2005.
DOI : 10.2174/156652305774329285

V. Escriou, M. Carriere, D. Scherman, P. Wils, Y. Vc et al., NLS bioconjugates for targeting therapeutic genes to the nucleus, Advanced Drug Delivery Reviews, vol.55, issue.2, pp.295-306, 2003.
DOI : 10.1016/S0169-409X(02)00184-9

I. Fajac, S. Grosse, J. Collombet, G. Thevenot, S. Goussard et al., Recombinant Escherichia coli as a gene delivery vector into airway epithelial cells, Journal of Controlled Release, vol.97, issue.2, pp.371-381, 2004.
DOI : 10.1016/j.jconrel.2004.03.025

E. Fattal, C. Dubernet, and P. Couvreur, Liposome-based formulations for the delivery of oligonucleotides, STP pharma sciences, vol.11, issue.1, pp.31-44, 2001.

A. Fluckiger, C. Dehay, and P. Savatier, Cellules souches embryonnaires et thérapies cellulaires du système nerveux Embryonic stem cells and cell replacement therapies in the nervous system, MS Medecine sciences, vol.19, pp.6-7, 2003.

C. Fraefel, ?. Mendes, A. Madeira, O. Mabon, A. Lefebvre et al., In vivo gene transfer to the rat retina using herpes simplex virus type 1 (HSV-1)-based amplicon vectors, Gene Therapy, vol.186, issue.16, pp.1283-1288, 2005.
DOI : 10.1038/sj.gt.3302553

G. Fuhrmann, Production de cellules germinales ?? partir de cellules souches embryonnaires de souris en culture, Gyn??cologie Obst??trique & Fertilit??, vol.33, issue.10, pp.813-818, 2005.
DOI : 10.1016/j.gyobfe.2005.07.039

URL : https://hal.archives-ouvertes.fr/hal-00129863

A. Funhoff, S. Monge, R. Teeuwen, G. Koning, N. Schuurmans-nieuwenbroek et al., PEG shielded polymeric double-layered micelles for gene delivery, Journal of Controlled Release, vol.102, issue.3, pp.711-724, 2005.
DOI : 10.1016/j.jconrel.2004.11.005

R. Gerolami, R. Uch, J. Faivre, S. Garcia, J. Hardwigsen et al., Herpes simplex virus thymidine kinase-mediated suicide gene therapy for hepatocellular carcinoma using HIV-1-derived lentiviral vectors, Journal of Hepatology, vol.40, issue.2, pp.291-297, 2004.
DOI : 10.1016/j.jhep.2003.10.019

H. Gilgenkrantz, J. Guidotti, C. Mitchell, V. Mallet, and A. Kahn, Stratégies de repeuplement du foie: Cellules souches et réparation tissulaire Liver repopulation strategies, Bulletin de l'Academie nationale de medecine, vol.189, issue.4, pp.625-633, 2005.

J. Grill, B. Geoerger, M. Lamfers, C. Dirven, V. Beusechem et al., Les adénovirus réplicatifs conditionnels : un second souffle pour la thérapie génique du cancer Conditionally replicative adenoviruses: a second wind for cancer gene therapy, Bulletin du cancer, issue.12, pp.90-1039, 2003.

F. Guillot, Production de kératinocytes autologues à buts thérapeutiques au sein d'un établissement pharmaceutique. Thérapie cellulaire Autologous keratinocyte production for cellular therapy within a pharmaceutical company. Cellular therapy, Journal de la Societe de biologie, vol.195, issue.1, pp.75-77, 2001.
DOI : 10.1051/jbio/2001195010075

J. Haiech, Strategies post-genomique: Strategies contre le cancer Post-genomic strategies, Biofutur Puteaux, vol.245, pp.22-23, 2004.

P. Henning, K. Andersson, K. Frykholm, A. Ali, M. Magnusson et al., Tumor cell targeted gene delivery by adenovirus 5 vectors carrying knobless fibers with antibody-binding domains, Gene Therapy, vol.12, issue.3, pp.211-224, 2005.
DOI : 10.1038/sj.gt.3302408

URL : https://hal.archives-ouvertes.fr/hal-00123930

D. Hodgson, A. Behfar, L. Zingman, G. Kane, T. Perez et al., Stable benefit of embryonic stem cell therapy in myocardial infarction, AJP: Heart and Circulatory Physiology, vol.287, issue.2, pp.471-479, 2004.
DOI : 10.1152/ajpheart.01247.2003

A. Jouneau and J. Renard, Cellules souches embryonnaires et clonage thérapeutique Embryonic stem cells and therapeutic cloning, MS Medecine sciences, vol.18, issue.2, pp.169-180, 2002.
DOI : 10.1051/medsci/2002182169

N. Kubis and M. Catala, Les cellules-souches, un outil thérapeutique pour le futur? L'embryologie appliquée a la Neurochirurgie (I) Neurosurgical embryology. Part 4: What are stem-cells? Neurosurgical embryology (I), Neuro chirurgie Paris, vol.49, issue.4, pp.449-456, 2003.

A. Laner, S. Goussard, A. Ramalho, T. Schwarz, M. Amaral et al., Bacterial transfer of large functional genomic DNA into human cells, Gene Therapy, vol.28, issue.21, pp.1559-1572, 2005.
DOI : 10.1093/hmg/7.4.729

H. Lauterbach, C. Ried, A. Epstein, P. Marconi, and T. Brocker, Reduced immune responses after vaccination with a recombinant herpes simplex virus type 1 vector in the presence of antiviral immunity, Journal of General Virology, vol.86, issue.9, pp.2401-2410, 2005.
DOI : 10.1099/vir.0.81104-0

URL : https://hal.archives-ouvertes.fr/hal-00144427

C. Leclerc and P. Moingeon, Les vaccins du futur. Le péril infectieux: quelles stratégies de lutte? Vaccines of the future, Biofutur Puteaux, vol.217, pp.82-86, 2001.

G. Leclerc and S. Rebuffat, NOUVEAUX PEPTIDES ANTIBIOTIQUES DE CHAMPIGNONS TRICHODERMA Biosynthèses dirigées Isolement, purification et caractérisation de la peptaibol-synthetase de T. longibrachiatum NEW PEPTIDE ANTIBIOTICS FROM TRICHODERMA FUNGI Directed biosynthesis Isolation, purification and characterisation of the peptaibol synthetase from T, 2000.

C. Lorin, F. Delebecque, V. Labrousse, D. Silva, L. Lemonnier et al., A recombinant live attenuated measles vaccine vector primes effective HLA-A0201-restricted cytotoxic T lymphocytes and broadly neutralizing antibodies against HIV-1 conserved epitopes, Vaccine, vol.23, issue.36, pp.4463-4472, 2005.
DOI : 10.1016/j.vaccine.2005.04.024

URL : https://hal.archives-ouvertes.fr/pasteur-00013659

C. Lorin, L. Mollet, F. Delebecque, C. Combredet, B. Hurtrel et al., A Single Injection of Recombinant Measles Virus Vaccines Expressing Human Immunodeficiency Virus (HIV) Type 1 Clade B Envelope Glycoproteins Induces Neutralizing Antibodies and Cellular Immune Responses to HIV, Journal of Virology, vol.78, issue.1, pp.146-157, 2004.
DOI : 10.1128/JVI.78.1.146-157.2004

K. Lundstrom, C. Bagnis, O. Merten, and M. Mezzina, Biology and application of alphaviruses in gene therapy, Gene Therapy, vol.9, issue.SUP1, pp.92-97, 2005.
DOI : 10.1016/j.jneumeth.2003.09.029

C. Madzak and S. Pandalai, New tools for heterologous protein production in the yeast Yarrowia lipolytica. Recent research developments in microbiology, 2003.

J. Maffrand, J. Lehner, L. Fur, and G. , Conceptions et naissances des médicaments : La vie du médicament Design and birth of drugs: The life of drugs, La Revue du praticien Paris, vol.52, issue.5, pp.482-485, 2002.

C. Manuel, C. Lafon, D. Hairion, and S. Antoniotti, Cellules souches et clonage thérapeutique, des perspectives médicales en débat Stem cells and therapeutic cloning: medical perspectives under discussion, La Presse medicale, issue.5, pp.33-297, 1983.
DOI : 10.1016/s0755-4982(04)98568-5

B. Martin, M. Sainlos, A. Aissaoui, N. Oudrhiri, M. Hauchecorne et al., The Design of Cationic Lipids for Gene Delivery, Current Pharmaceutical Design, vol.11, issue.3, pp.375-394, 2005.
DOI : 10.2174/1381612053382133

P. Menasche, Embryonic stem cells pace the heart, Nature Biotechnology, vol.96, issue.10, pp.1237-1238, 2004.
DOI : 10.1152/ajpheart.01247.2003

R. Menassa, A. Jevnikar, J. Brandle, J. Toutant, and E. Balazs, A contained system for the field production of plant recombinant proteins. Molecular farming, pp.3-6, 2001.

M. Mevelec, D. Bout, B. Desolme, H. Marchand, R. Magne et al., Evaluation of protective effect of DNA vaccination with genes encoding antigens GRA4 and SAG1 associated with GM-CSF plasmid, against acute, chronical and congenital toxoplasmosis in mice, Vaccine, vol.23, issue.36, pp.4489-4499, 2005.
DOI : 10.1016/j.vaccine.2005.04.025

J. Miller, D. Becker, B. Dugdale, R. Harding, J. Aaskov et al., Towards the development of edible vaccines for human papillomavirus in bananas. Molecular farming, pp.3-6, 2000.

F. Molinier and P. Boulanger, Les adénovirus: de la structure à la vectorisation de gènes et à la vaccinologie. I: Virologie des adénovirus et des adénovirus recombinants Adenovirus: from structure to genes vectorisation and vaccinology, Virologie Montrouge, vol.7, issue.4, pp.267-279, 2003.

R. Morenweiser, C. Bagnis, O. Merten, and M. Mezzina, Downstream processing of viral vectors and vaccines, Gene Therapy, vol.72, issue.SUP1, pp.103-110, 2005.
DOI : 10.1073/pnas.0409141102

B. Mullan, C. Dugue, V. Moutard, D. Raoux, G. Tremp et al., Robust functional gene validation by adenoviral vectors: one-step Escherichia coli-Derived Recombinant Adenoviral Genome construction, Gene Therapy, vol.11, issue.21, pp.1599-1605, 2004.
DOI : 10.1038/sj.gt.3302333

E. Papapetrou, N. Zoumbos, A. Athanassiadou, C. Bagnis, O. Merten et al., Genetic modification of hematopoietic stem cells with nonviral systems: past progress and future prospects, Gene Therapy, vol.8, issue.SUP1, pp.118-130, 2005.
DOI : 10.1002/jgm.511

D. Pellerin, Cellules souches et th??rapie cellulaire. Contribution au d??bat ??thique, Comptes Rendus Biologies, vol.325, issue.10, pp.1059-1063, 2002.
DOI : 10.1016/S1631-0691(02)01518-4

R. Pergolizzi, R. Dragos, A. Ropper, A. Menez, and R. Crystal, Protective Immunity Against ??-Cobratoxin Following a Single Administration of a Genetic Vaccine Encoding a Non-Toxic Cobratoxin Variant, Human Gene Therapy, vol.16, issue.3, pp.292-298, 2005.
DOI : 10.1089/hum.2005.16.292

A. Perrier, Des cellules souches embryonnaires humaines pour le traitement de la maladie de Parkinson? Human embryonic stem cell in Parkinson's disease therapy?, MS Medecine sciences, vol.21, issue.1, pp.11-13, 2005.

H. Petite and D. Hannouche, Marrow Stromal Stem Cells for Repairing the Skeleton, Biotechnology and Genetic Engineering Reviews, vol.2, issue.1, pp.83-101, 2002.
DOI : 10.1080/02648725.2002.10648024

X. Preville, D. Ladant, B. Timmerman, and C. Leclerc, Eradication of established tumors by vaccination with recombinant Bordetella pertussis adenylate cyclase carrying the human papillomavirus 16 E7 oncoprotein, Cancer research Baltimore, vol.65, issue.2, pp.641-649, 2005.

J. Prugnaud, Les vaccins a ADN DNA vaccines, Annales pharmaceutiques francaises, vol.61, issue.4, pp.219-233, 2003.

I. Rance, F. Norre, V. Gruber, and M. Theisen, Combination of viral promoter sequences to generate highly active promoters for heterologous therapeutic protein over-expression in plants, Plant Science, vol.162, issue.5, pp.833-842, 2002.
DOI : 10.1016/S0168-9452(02)00031-6

Z. Raykov, V. Legrand, H. Homann, and J. Rommelaere, Transient suppression of transgene expression by means of antisense oligonucleotides: a method for the production of toxin-transducing recombinant viruses, Gene Therapy, vol.9, issue.5, pp.358-362, 2002.
DOI : 10.1038/sj.gt.3301660

J. Reimund, J. Haiech, M. Hibert, and C. Muller, Biotechnologie du médicament: nouvelles stratégies en recherche pharmacologique Drug biotechnology: news strategies in pharmacologic research, Hepato gastro Montrouge, vol.9, issue.1, pp.19-24, 2002.

L. Ribeiro, V. Azevedo, L. Loir, Y. Oliveira, S. Dieye et al., Production and Targeting of the Brucella abortus Antigen L7/L12 in Lactococcus lactis: a First Step towards Food-Grade Live Vaccines against Brucellosis, Applied and Environmental Microbiology, vol.68, issue.2, pp.910-916, 2002.
DOI : 10.1128/AEM.68.2.910-916.2002

URL : https://hal.archives-ouvertes.fr/hal-01128547

E. Richard, E. Robert, A. Cario, C. Ged, F. Geronimi et al., Hematopoietic stem cell gene therapy of murine protoporphyria by methylguanine-DNA-methyltransferase-mediated in vivo drug selection, Gene Therapy, vol.11, issue.22, pp.1638-1647, 2004.
DOI : 10.1038/sj.gt.3302335

D. Roux, P. Chenevier, T. Pott, L. Navailles, O. Regev et al., Conception and Realization of a Non-Cationic Non-Viral DNA Vector, Current Medicinal Chemistry, vol.11, issue.2, pp.169-177, 2004.
DOI : 10.2174/0929867043456133

A. Sahin, E. Tetaud, G. Merlin, and X. Santarelli, LdARL-1 His-tagged recombinant protein: purification by immobilized metal affinity expanded bed adsorption, Journal of Chromatography B, vol.818, issue.1, pp.19-22, 2005.
DOI : 10.1016/j.jchromb.2004.10.022

URL : https://hal.archives-ouvertes.fr/hal-00069234

F. Sainteny, Production de cellules hématopoïétiques à partir des cellules ES. Thérapie cellulaire Production of hematopoietic cells from ES cells. Cellular therapy, Journal de la Societe de biologie, vol.195, issue.1, pp.13-18, 2001.
DOI : 10.1051/jbio/2001195010013

D. Serruto, B. Adu, B. Capecchi, R. Rappuoli, M. Pizza et al., Biotechnology and vaccines: application of functional genomics to Neisseria meningitidis and other bacterial pathogens, Highlights from the ECB11: Building Bridges between Biosciences and Bioengineering, pp.1-3, 2004.
DOI : 10.1016/j.jbiotec.2004.03.024

R. Sodoyer and L. Aujame, L'ingénierie des anticorps aujourd'hui: Obésite, anticorps, tumeurs: quelles avancées? Antibodies engineering, Biofutur Puteaux, vol.241, pp.22-25, 2004.

M. Sosio, F. Giusino, C. Cappellano, E. Bossi, A. Puglia et al., Artificial chromosomes for antibiotic-producing actinomycetes, Nature biotechnology, vol.18, issue.3, pp.343-345, 2000.

M. Szelechowski and A. Saib, Une nouvelle arme contre le cancer: bilan sur les virus oncolytiques Insights into a new weapon against cancer: oncolytic viruses, Virologie Montrouge, vol.9, issue.4, pp.261-271, 2005.

A. Tonnel, A. Tsicopoulos, and H. Hammad, Les thérapeutiques du futur en allergologie. Cytokines recombinantes, anticytokines, antagonistes des récepteurs de cytokines et inhibiteurs des molécules costimulatrices. Journées nationales de la Société française d'allergologie et d'immunologie clinique, pp.13-15, 2000.

J. Trouvin, Sécurité sanitaire des OGM utilisés en thérapeutique Health security -GMOs in therapeutics, Annales pharmaceutiques francaises, vol.61, issue.2, pp.103-108, 2003.

K. Tsang, Z. Mingzhu, J. Even, J. Gulley, P. Arlen et al., The infection of human dendritic cells with recombinant avipox vectors expressing a costimulatory molecule transgene (CD80) to enhance the activation of antigen-specific cytolytic T cells, Cancer research Baltimore, issue.20, pp.61-7568, 2001.

T. Tuboly, W. Yu, A. Bailey, L. Erickson, E. Nagy et al., Development of oral vaccine in plants against transmissible gastroenteritis virus of swine. Molecular farming, pp.3-6, 2000.

G. Uzan, Utilisation thérapeutique des cellules souches. II. Les cellules souches adultes Therapeutic use of stem cells: II. Adult stem cells, La Revue du praticien Paris, vol.54, issue.14, pp.1515-1527, 2004.

L. Vallier and J. Samarut, Mise au point d'un système d'expression inductible dans les cellules Souches Embryonnaires An efficient system for conditionel gene expression in embryonnic stem cells, 2001.

V. Van-beusechem, D. Mastenbroek, . Van-den, P. Doel, M. Lamfers et al., Conditionally replicative adenovirus expressing a targeting adapter molecule exhibits enhanced oncolytic potency on CAR-deficient tumors, Gene Therapy, vol.10, issue.23, pp.1982-1991, 2003.
DOI : 10.1038/sj.gt.3302103

A. Weber, Les cellules souches??: espoir de la th??rapie cellulaire, Pathologie Biologie, vol.51, issue.7, pp.432-433, 2003.
DOI : 10.1016/S0369-8114(03)00129-9

K. Weigel, A. Srivastava, and M. Fc, Recombinant human parvovirus B19 vectors, Pathologie Biologie, vol.50, issue.5, pp.295-306, 2002.
DOI : 10.1016/S0369-8114(02)00310-3

P. Yotnda, B. Savoldo, B. Charlet, C. Rooney, and M. Brenner, Targeted delivery of adenoviral vectors by cytotoxic T cells, Blood, vol.104, issue.8, pp.2272-2280, 2004.
DOI : 10.1182/blood-2003-11-3803

G. Zuber, Nanoparticules d'ADN: Nanobiotechnologies: des avancees pour les sciences du vivant DNA nanoparticles, Biofutur Puteaux, vol.249, pp.46-49, 2004.