Is There One Key Step in the Metastatic Cascade? - CRLC Val d'Aurelle - Paul Lamarque Accéder directement au contenu
Article Dans Une Revue Cancers Année : 2021

Is There One Key Step in the Metastatic Cascade?

Jean-Pascal Capp

Résumé

The majority of cancer-related deaths are the result of metastases (i.e., dissemination and establishment of tumor cells at distant sites from the origin), which develop through a multi-step process classically termed the metastatic cascade. The respective contributions of each step to the metastatic process are well described but are also currently not completely understood. Is there, for example, a critical phase that disproportionately affects the probability of the development of metastases in individual patients? Here, we address this question using a modified Drake equation, initially formulated by the astrophysicist Frank Drake to estimate the probability of the emergence of intelligent civilizations in the Milky Way. Using simulations based on realistic parameter values obtained from the literature for breast cancer, we examine, under the linear progression hypothesis, the contribution of each component of the metastatic cascade. Simulations demonstrate that the most critical parameter governing the formation of clinical metastases is the survival duration of circulating tumor cells (CTCs).

Domaines

Cancer
Fichier principal
Vignette du fichier
2021_Dujon_Cancers.pdf (2.45 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
licence : CC BY - Paternité

Dates et versions

hal-03442172 , version 1 (23-11-2021)

Licence

Paternité

Identifiants

Citer

Antoine M Dujon, Joel S. Brown, Jean-Pascal Capp, Pascal Pujol, Robert A Gatenby, et al.. Is There One Key Step in the Metastatic Cascade?. Cancers, 2021, 13 (15), pp.3693. ⟨10.3390/cancers13153693⟩. ⟨hal-03442172⟩
52 Consultations
31 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More