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Theses

Utilisation des antiviraux dans le traitement de la grippe

Abstract : Despite numerous studies carried out and the consensus recommendations at international level, the prescription of neuraminidase inhibitors (NIs) in case of flu syndrome remains controversial. This thesis aimed to better understand the place that NIs should have for the treatment of seasonal and pandemic influenza.To answer this question, several studies have been conducted and have shown:-A lower efficacy of a combination of oseltamivir + zanamivir than oseltamivir alone in the treatment of influenza patients to reduce the duration of illness and viral nasopharyngeal carriage, while an opposite effect was observed on transmission of influenza when the combination therapy was administered within 24 hours of onset of symptoms;-Several factors related to the characteristics of the patient and the virus infection with clinical and virological response during treatment with oseltamivir or zanamivir, especially with a possible efficacy of oseltamivir lower in women;-The reluctance of physicians to systematically implement the recommendations concerning the prescription of NIs in case of influenza syndrome in patients at risk for complicated influenza, in particular during seasonal epidemics.It appears particularly important to better understand the barriers associated with the prescription of NIs and improve the use of these treatments in the years to come.
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  • HAL Id : tel-03208484, version 1

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Thierry Blanchon. Utilisation des antiviraux dans le traitement de la grippe. Médecine humaine et pathologie. Université Pierre et Marie Curie - Paris VI, 2015. Français. ⟨NNT : 2015PA066742⟩. ⟨tel-03208484⟩

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