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Influence de l’hydrodynamique sur les régimes de capture à une surface solide

Abstract : The capture of objects on a solid surface in a laminar flow is involved in many applications, notably in bionanalysis and biological research. Studied since the beginning of the 20th century, this capture involves three mechanisms: convection of the object by the liquid above the capture surface, diffusion of the object towards this surface and finally reaction kinetics at the surface. Until now, the capture models present in he literature are designed for continuously injected molecules. However, many common situations in biotechnology do not correspond to this case. They involve, for example, more complex objects (nano/microparticles, deformable objects,...) or objects injected as small plugs. The objective of this thesis is, thanks to experiments, numerical simulations, and theoretical models, to propose new capture laws adapted to these common situations of modern bioanalysis. It will be shown that three phenomena must respectively be taken into account in these new capture laws in order to understand the specificity of each of these situations: the inertial lift effect (for particles), the elastic lift effect (for deformable objects) and the Taylor-Aris dispersion for small volume samples)
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Submitted on : Friday, September 3, 2021 - 5:02:17 PM
Last modification on : Friday, November 25, 2022 - 4:02:50 AM
Long-term archiving on: : Saturday, December 4, 2021 - 8:02:19 PM


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  • HAL Id : tel-03334410, version 1


Donatien Mottin. Influence de l’hydrodynamique sur les régimes de capture à une surface solide. Physique [physics]. École normale supérieure de Rennes, 2021. Français. ⟨NNT : 2021ENSR0027⟩. ⟨tel-03334410⟩



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