Electrochemical Skin Conductance and Quantitative Sensory Testing on Fibromyalgia

Gisèle Pickering (1, 2) , Alexanne Achard (1) , Alexandrine Corriger (1, 2) , Sophia Sickout‐arondo (1) , Nicolas Macian (1) , Vincent Leray (1) , Camille Lucchini (1) , Jean-Michel Cardot (3) , Bruno Pereira (4)

1 CIC 1405 - Centre d'Investigation Clinique [CHU Clermont-Ferrand]
2 Neuro-Dol - Neuro-Dol
3 MEDIS - Microbiologie Environnement Digestif Santé
4 UNICANCER/CJP - Centre Jean Perrin [Clermont-Ferrand]

Background: An impairment of the peripheral nervous system has been suggested in fibromyalgia (FM). Noninvasive distal electrochemical skin conductance (ESC) has been studied little so far when combined with quantitative sensory testing (QST) in patients with FM. Methods: This study (clinicaltrials.govNCT03347669) included 50 female patients with FM and 50 matched healthy volunteers (HVs). ESC (measured in microsiemens [µS] with Sudoscan), as well as psychological, quality of life, sleep, and social characteristics, were assessed in both groups. In a subgroup o f24 patients with FM and 24 HVs, QST of cold and warm detection and pain thresholds and diffuse noxious inhibitory controls (DNICs) were explored. Statistical analysis was performed for a 2-sided type I error at 5%.

Mots clés: Sudoscan; sweat glands; neuropathy; small nerve fibers; fibromyalgia

Domaines: Sciences du Vivant [q-bio]

Gisèle Pickering, Alexanne Achard, Alexandrine Corriger, Sophia Sickout‐arondo, Nicolas Macian, et al.. Electrochemical Skin Conductance and Quantitative Sensory Testing on Fibromyalgia. Pain Practice, 2020, 20 (4), pp.348-356. ⟨10.1111/papr.12857⟩. ⟨hal-02935679⟩