ATG16L1 in myeloid cells limits colorectal tumor growth in Apc ^Min/+ mice infected with colibactin-producing Escherichia coli via decreasing inflammasome activation

Laurène Salesse , Angéline Duval , Pierre Sauvanet , Alison da Silva , Nicolas Barnich , Catherine Godfraind , Guillaume Dalmasso (1) , Hang Thi Thu Nguyen

1 M2iSH - Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte

Keywords: AOM; azoxymethane APC; APC regulator of WNT signaling pathway ATG; autophagy related Atg16l1[∆MC] mice; mice deficient for Atg16l1 specifically in myeloid cells CASP1; caspase 1 BMDM; bone marrow-derived macrophage CFU; colony-forming unit CoPEC; colibactin-producing Escherichia coli CRC; colorectal cancer CXCL1/KC; C-X-C motif chemokine ligand 1 ELISA; enzyme-linked immunosorbent assay IL; interleukin MC; myeloid cell MOI; multiplicity of infection PBS; phosphatebuffered saline pks; polyketide synthase qRT-PCR; quantitative real-time reverse-transcription polymerase chain reaction siRNA; small interfering RNA TME; tumor microenvironment TNF/TNF-α; tumor necrosis factor Autophagy bacterial infection colibactinproducing E. coli colorectal cancer toxin; azoxymethane; APC; APC regulator of WNT signaling pathway; ATG; autophagy related; Atg16l1[∆MC] mice; mice deficient for Atg16l1 specifically in myeloid cells; CASP1; caspase 1; BMDM; bone marrow-derived macrophage; CFU; colony-forming unit; CoPEC; colibactin-producing Escherichia coli; CRC; colorectal cancer; CXCL1/KC; C-X-C motif chemokine ligand 1; ELISA; enzyme-linked immunosorbent assay; IL; interleukin; MC; myeloid cell; MOI; multiplicity of infection; PBS; phosphatebuffered saline; pks; polyketide synthase; qRT-PCR; quantitative real-time reverse-transcription polymerase chain reaction; siRNA; small interfering RNA; TME; tumor microenvironment; TNF/TNF-α; tumor necrosis factor Autophagy; bacterial infection; colibactinproducing E. coli; toxin

Domains: Life Sciences [q-bio]

Laurène Salesse, Angéline Duval, Pierre Sauvanet, Alison da Silva, Nicolas Barnich, et al.. ATG16L1 in myeloid cells limits colorectal tumor growth in Apc ^Min/+ mice infected with colibactin-producing Escherichia coli via decreasing inflammasome activation. Autophagy, 2024, pp.1 - 19. ⟨10.1080/15548627.2024.2359770⟩. ⟨hal-04654209⟩