Application and methodology of dissolution dynamic nuclear polarization in physical, chemical and biological contexts

Sami Jannin (1) , Jean-Nicolas Dumez (2) , Patrick Giraudeau (2) , Dennis Kurzbach (3)

1 CRMN - Centre de RMN à très hauts champs de Lyon
2 CEISAM - Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation
3 LBM-E3 - Structure et Dynamique des Biomolécules

Dissolution dynamic nuclear polarization (d-DNP) is a versatile method to enhance nuclear magnetic resonance (NMR) spectroscopy. It boosts signal intensities by four to five orders of magnitude thereby providing the potential to improve and enable a plethora of applications ranging from the real-time monitoring of chemical or biological processes to metabolomics and in-cell investigations. This perspectives article highlights possible avenues for developments and applications of d-DNP in biochemical and physicochemical studies. It outlines how chemists, biologists and physicists with various fields of interest can transform and employ d-DNP as a powerful characterization method for their research.

Domaines: Chimie analytique; Chimie

Sami Jannin, Jean-Nicolas Dumez, Patrick Giraudeau, Dennis Kurzbach. Application and methodology of dissolution dynamic nuclear polarization in physical, chemical and biological contexts. Journal of Magnetic Resonance, 2019, 305, pp.41-50. ⟨10.1016/j.jmr.2019.06.001⟩. ⟨hal-02189491⟩