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Journal articles

Antimicrobial resistance in enterobacterales recovered from urinary tract infections in France

E. Farfour 1, * L. Dortet 2 Thomas Guillard 3, 4 N. Chatelain 5 A. Poisson 6 A. Mizrahi 7 D. Fournier 8 R.A. Bonnin 2 N. Degand 9 P. Morand 10 F. Janvier 11 V. Fihman 12 S. Corvec 13 L. Broutin 14 Cécile Le Brun 15 N. yin 16, 17, 18 G. Héry-Arnaud 19 A. Grillon 20 E. Bille 21 H. Jean-Pierre 22 M. Amara 23 F. Jaureguy 24 C. Isnard 25 Vincent Cattoir 26, 27 T. Diedrich 28 E. Flevin 29 A. Merens 30 H. Jacquier 31 M. Vasse 1 
* Corresponding author
18 Microbiologie
Département de biologie et pathologie médicales [Gustave Roussy]
Abstract : In the context of increasing antimicrobial resistance in Enterobacterales, the management of these UTIs has become challenging. We retrospectively assess the prevalence of antimicrobial resistance in Enterobacterales isolates recovered from urinary tract samples in France, between 1 September 2017, to 31 August 2018. Twenty-six French clinical laboratories provided the susceptibility of 134,162 Enterobacterales isolates to 17 antimicrobials. The most frequent species were $E.\ coli$ (72.0%), $Klebsiella\ pneumoniae$ (9.7%), $Proteus\ mirabilis$ (5.8%), and $Enterobacter\ cloacae$ complex (2.9%). The overall rate of ESBL-producing Enterobacterales was 6.7%, and ranged from 1.0% in $P.\ mirabilis$ to 19.5% in $K.\ pneumoniae$, and from 3.1% in outpatients to 13.6% in long-term care facilities. Overall, 4.1%, 9.3% and 10.5% of the isolates were resistant to cefoxitin, temocillin and pivmecillinam. Cotrimoxazole was the less active compound with 23.4% resistance. Conversely, 4.4%, 12.9%, and 14.3% of the strains were resistant to fosfomycin, nitrofurantoin, and ciprofloxacin. However, less than 1% of E. coli was resistant to fosfomycin and nitrofurantoin. We identified several trends in antibiotics resistances among Enterobacterales isolates recovered from the urinary tract samples in France. Carbapenem-sparing drugs, such as temocillin, mecillinam, fosfomycin, cefoxitin, and nitrofurantoin, remained highly active, including towards ESBL-E.
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Submitted on : Wednesday, April 6, 2022 - 4:33:42 PM
Last modification on : Wednesday, July 6, 2022 - 9:29:01 AM


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E. Farfour, L. Dortet, Thomas Guillard, N. Chatelain, A. Poisson, et al.. Antimicrobial resistance in enterobacterales recovered from urinary tract infections in France. Pathogens, MDPI, 2022, 11 (3), pp.356. ⟨10.3390/pathogens11030356⟩. ⟨hal-03633007⟩



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