Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms

G. Frega (1) , O. Kepp (2, 3) , D. Turchetti (1) , A. Rizzo (1) , M.A. A Pantaleo (1) , G. Brandi (1)

1 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
2 CRC (UMR_S_1138 / U1138) - Centre de Recherche des Cordeliers
3 IGR - Institut Gustave Roussy

The genetic background and the antigenic landscape of cancer cells play a critical role in the response to immunotherapies. A high tumor antigenicity, together with an increased adjuvanticity potentially induced by a peculiar type of cell death, namely immunogenic cell death (ICD), could foster the response to immunogenic therapies. The gestational trophoblastic neoplasm (GTN) is a one-of-a-kind cancer in the oncological landscape due to its exclusive genomic makeup. The prognosis of GTN is significantly better than non-gestational trophoblastic neoplasm (nGTN). Due to its peculiar genetic inheritance, GTN potentially constitutes a singular archetype in the immuno-oncological field.

Mots clés: Immunogenic cell death; Immunomodulatory chemotherapies; Cancer genome; Gestational choriocarcinoma; Bystander effect

Domaines: Médecine humaine et pathologie

G. Frega, O. Kepp, D. Turchetti, A. Rizzo, M.A. A Pantaleo, et al.. Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms. Translational Oncology, 2021, 14 (12), pp.101224. ⟨10.1016/j.tranon.2021.101224⟩. ⟨hal-03369979⟩