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Derniers articles publiés

[hal-03495708] Prevalence of white matter pathways coming into a single white matter voxel orientation: The bottleneck issue in tractography

(04/01/2022)  
Characterizing and understanding the limitations of diffusion MRI fiber tractographyis a prerequisite for methodological advances and innovations which will allow thesetechniques to accurately map the connections of the human brain. The so-called“crossing fiber problem”has received tremendous attention and has continuouslytriggered the community to develop novel approaches for disentangling distinctly ori-ented fiber populations. Perhaps an even greater challenge occurs when multiplewhite matter bundles converge within a single voxel, or throughout a single brainregion, and share the same parallel orientation, before diverging and continuingtowards their final cortical or sub-cortical terminations. These so-called“bottleneck”regions contribute to the ill-posed nature of the tractography process, and lead toboth false positive and false negative estimated connections. Yet, as opposed to theextent of crossing fibers, a thorough characterization of bottleneck regions has notbeen performed. The aim of this study is to quantify the prevalence of bottleneckregions. To do this, we use diffusion tractography to segment known white matterbundles of the brain, and assign each bundle to voxels they pass through and to spe-cific orientations within those voxels (i.e. fixels). We demonstrate that bottlenecksoccur in greater than 50-70% of fixels in the white matter of the human brain. We find that all projection, association, and commissural fibers contribute to, and areaffected by, this phenomenon, and show that even regions traditionally considered“single fiber voxels”often contain multiple fiber populations. Together, this studyshows that a majority of white matter presents bottlenecks for tractography whichmay lead to incorrect or erroneous estimates of brain connectivity or quantitativetractography (i.e., tractometry), and underscores the need for a paradigm shift in theprocess of tractography and bundle segmentation for studying the fiber pathways ofthe human brain.

[hal-03337960] Novel characterization of the relationship between verbal list‐learning outcomes and hippocampal subfields in healthy adults

(04/01/2022)  

[hal-03346646] Functionnectome as a framework to analyse the contribution of brain circuits to fMRI.

(04/01/2022)  

[hal-03314914] An Integrated Clinical-Biological Approach to Identify Interindividual Variability and Atypical Phenotype-Genotype Correlations in Myopathies: Experience on A Cohort of 156 Families

(03/12/2021)  

[hal-03346941] The MRi-Share database: brain imaging in a cross-sectional cohort of 1,870 university students.

(18/09/2021)  

[hal-03495751] Reply to the letter to the Editor

(04/01/2022)  

[hal-03346557] Filtering in tractography using autoencoders (FINTA)

(17/09/2021)  

[hal-03242838] The Role of White Matter Disconnection in the Symptoms Relating to the Anarchic Hand Syndrome: A Single Case Study

(04/12/2021)  

[hal-03345943] The inferior fronto-occipital fascicle: a century of controversies from anatomy theaters to operative neurosurgery.

(17/09/2021)  

[hal-03224904] Hodology of the superior longitudinal system of the human brain: a historical perspective, the current controversies, and a proposal

(13/05/2021)  

 

 

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Genome-wide association studies Diffusion imaging Depression Neuroanatomy Functional connectivity Post-adolescence Spatial attention Tractography Données Hétérogènes DTI Gestion des données Brain volume Cortical surface area Neuroscience Basal ganglia Heschl’s gyrus Cerebrovascular disorders Functional magnetic resonance imaging Speech Language Dissection Langage FMRI Hypertension Brain Theory of mind Mouse model Congenital myopathies PLM Hemispheric lateralization Hemispheric specialization Product Lifecycle Management Lateralization MRI Cognition Cohort studies Stroke Familial sinistrality Multidimensional data Hippocampus Brain atrophy Nomenclature Hemispheric dominance Association pathways Heschl's gyrus Calcium Emotion Human brain Cerebral small vessel diseases Language production Sex Uncinate fasciculus Connectivity Fiber tractography Human brain anatomy Reproducibility Intrinsic connectivity Asymmetry Neuroimagerie Pseudoneglect Genetic Neuroimaging Excitation-contraction coupling Graph Theory Corpus callosum Exploration Neurosurgery Laterality Functional MRI Imaging Cortical thickness Skeletal muscle Diffusion tensor imaging Heterogeneous Data Gray matter White matter Resting state Fiber pathways Schizophrenia Bundle segmentation Handedness Data Management Diffusion Données Multidimensionnelles Anatomy Prosody Inferior fronto-occipital fasciculus Inferior fronto-occipital fascicle Aging Atlas Magnetic resonance imaging Diffusion MRI Inhibition Bio-Medical Imaging BMI Product Lifecycle Management PLM White matter anatomy Atrophy NODDI Cohort Brain connectivity

 

 

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