Global Review of the Age Distribution of Rotavirus Disease in Children Aged <5 Years Before the Introduction of Rotavirus Vaccination

Mateusz Hasso-Agopsowicz , Nanji Ladva , Benjamin Lopman , Colin Sanderson , Adam L Cohen , Jacqueline E Tate , Ximena Riveros , Ana Maria Henao-Restrepo , Andrew E. Clark (1) , Chandresh Nanji Ladva , M Alkorta , C Atchison , S Banajeh , S Becker-Dreps , M Benhafid , N Bhandari , L Bodhidatta , T Braeckman , J Bwogi , R de Cassia Compagnoli Carmona , G. Cilla (2) , I Contreras-Roldan , B Coulson , N Cunliffe , R Dagan , N Givon , J Degiuseppe , S Dhiman , Z Dian , J. M. Díaz (3) , S Dutta , T Krishnan , B Manna , S Fletcher-Lartey , C Fu , D. Gendrel (4) , K. Ghenghesh (5) , G Gonzalez Mago , S de Grazia , K Grimwood , M Groome , A. Haque (6) , U Heininger , E Houpt , M. Iturriza-Gómara (7) , D Hungerford , C Jarquin , J Mccracken , I Contreras , C Cordon-Rosales , P Kaiser-Labusch , G Kang , S Kar , N Kiulia , K Kotloff , R Latipov , A Linhares , M. Lorrot (4) , M Mandile , C Mast , M. Mathew , F Matinon-Torres , J Matthijnssens , Z. Mladenova (8) , M Monini , M Montes , A Arana , M Motamedifar , A Najafi , T. Nelson (9) , J Nokes , F Ntoumi , K Numazaki , C O’reilly , T Ochoa , N Page , A. Page , C Langendorf , A Podkolzin , C Quach , M Racz , Alexis de Rougemont (10, 11, 12, 13) , G Ruiz-Palacios , S Saha , S Satter , L Soares , S Sudarmo , K Shigemura , T Shirakawa , A Athiyyah , B Tagbo , P Tarr , E. Klein (14) , D Denno , A. Turner (15) , E Uzoma , R Vatosoa , E Wandera , M Wikswo , D Payne , H Yhu-Chering , T Yoshikawa , K Sugata , Q Yuan , L Liying , K. Zaman , X -N Zhou , S -X Zhang , Wei-Jiang Xu , Fatima Serhan , Tomoka Nakamura , Sébastien Antoni , Mary Agócs , Jillian Murray , Thomas Cherian , Jason Mwenda , Goitom Weldegebriel , Joseph Biey , Dah Cheikh , Nadia Teleb , Hossam Abdel Rahman , Hinda Ahmed (16) , Danni Daniels , Dovile Videbaek , Annemarie Wasley , Simarjit Singh , Lucia de Oliveira , Gloria Rey-Benito , N Jennifer Sanwogou , Jayantha P. Liyanage (17) , Pushpa Ranjan Wijesinghe , Nyambat Batmunkh , Varja Grabovac , Kimberley Fox , Fem Julia Paladin , Nicholas Henschke

1 QUT - Queensland University of Technology [Brisbane]
2 Microbiology Service
3 GIEMA - Grupo de Investigación en Energía y Medioambiente [Bucaramanga]]
4 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
5 University of Tripoli - University Al Fateh
6 Visva Bharati University
7 Enteric Virus Unit, Virus Reference Department, Centre for Infections
8 Department of Virology, National Reference Laboratory of Enteroviruses
9 Friction Stir Laboratory
10 UFR des Sciences de Santé (Université de Bourgogne)
11 CNR virus entériques - Centre National de Référence des virus entériques [CHU de Dijon]
12 Laboratoire de sérologie-virologie (CHU de Dijon)
13 PAM - Procédés Alimentaires et Microbiologiques [Dijon]
14 IBMP - Institut de Biologie Moléculaire des Plantes
15 School of Social and Community Medicine [Bristol]
16 Vaccine Preventable Disease and Immunization
17 University of Stavanger

We sought datasets with granular age distributions of rotavirus-positive disease presentations among children <5 years of age, before the introduction of rotavirus vaccines. We identified 117 datasets and fit parametric age distributions to each country dataset and mortality stratum. We calculated the median age and the cumulative proportion of rotavirus gastroenteritis events expected to occur at ages between birth and 5.0 years. The median age of rotavirus-positive hospital admissions was 38 weeks (interquartile range [IQR], 25-58 weeks) in countries with very high child mortality and 65 weeks (IQR, 40-107 weeks) in countries with very low or low child mortality. In countries with very high child mortality, 69% of rotavirus-positive admissions in children <5 years of age were in the first year of life, with 3% by 10 weeks, 8% by 15 weeks, and 27% by 26 weeks. This information is critical for assessing the potential benefits of alternative rotavirus vaccination schedules in different countries and for monitoring program impact.

Keywords: rotavirus; vaccine; age distribution; rotavirus gastroenteritis

Domains: Virology; Infectious diseases

Mateusz Hasso-Agopsowicz, Nanji Ladva, Benjamin Lopman, Colin Sanderson, Adam L Cohen, et al.. Global Review of the Age Distribution of Rotavirus Disease in Children Aged <5 Years Before the Introduction of Rotavirus Vaccination. Clinical Infectious Diseases, 2019, 69 (6), pp.1071-1078. ⟨10.1093/cid/ciz060⟩. ⟨hal-02291016⟩