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EUROPEAN RESEARCH LABORATORY FOR RHEUMATOID ARTHRITIS – GENHOTEL

European research laboratory for rheumatoid arthritis - GenHotel is a research unit of University of Evry since 1999 on the Genopole campus. For nearly 20 years, our lab has focused on the aetiology of a complex disease, rheumatoid arthritis (RA). After a period consisted of 'classical' genetic analyses through linkage and association studies, results, and particularly GWAS one, lead us to develop alternative approaches. Instead of considering common genomic variants, we decided to focus on rare and specific ones, to identify biomarkers in RA and its phenotypes. In this direction, we developed a global approach to the disease by mapping all the connections. Based on these approaches, our research activity is divided into two main axis: Characterization of new RA genomic variants and Computational systems biology approaches for the construction of graphical and dynamical models of disease mechanisms to study their complex dynamic behavior. Results of the first axis feed the second project, contributing to the development of a pipeline for identifying new lines in RA drug design.

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Antigens Genetic Alleles Biologie computationnelle des systèmes Network inference Receptors Complex genetic disease Genetic Linkage In silico simulations Hybrid modeling Rheumatoid Arthritis Patient Humans ABCB1 Biological pathway Biologie des systèmes European Continental Ancestry Group Computational systems biology Ankylosing PTPN22 gene Rheumatoid Factor Europe Protein Tyrosine Phosphatase ATP Binding Cassette Transporter Ankylosing spondylitis Single Nucleotide Anti-Idiotypic Annotation standards Tunisia Databases Autoimmune thyroid diseases HLA-DRB1 Chains Environment Binding Sites Rheumatoid Arthritis Family Health Analysis ASSOCIATION STUDY Case-Control Studies Arthritis Reproducibility Male Logical modelling APOPTOSIS Non-Receptor Type 22 Disease maps Epitopes Risk Factors Genotype Shared Epitope Gene Frequency Biocuration Human genomics Autoimmune thyroid disease Systems biology Autoimmune Diseases Haplotypes 80 and over Age of Onset Génétique POLYMORPHISM Genetic Predisposition to Disease Algeria Autoantibodies Odds Ratio France Family Aged Rheumatoid Anti-citrullinated protein antibodies Age Factors Genetic Association Studies HLA-DR Antigens Autoimmunity Phenotype Animals Cohort Studies Association study Young Adult Algerian population Autoantibody Production Adolescent Middle Aged Antigen Presentation Genetics Polyarthrite rhumatoïde Linkage Disequilibrium Computational biology Adult HLA-DRB1 African Continental Ancestry Group Computational modeling Rheumatoid arthritis Polymorphism Transcriptome Metabolic reprogramming Antirheumatic Agents Female RHEUMATOID ARTHRITIS Rare variants Antibodies

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