Impact of a specific training programme on the neuromodulation of pain in female patient with fibromyalgia (DouFiSport): a 24-month, controlled, randomised, double-blind protocol

Anais Le Fur Bonnabesse (1, 2, 3) , Mathilde Cabon (1) , Gildas L’heveder (2) , Aurélie Kermarrec (4) , Bertrand Quinio (2) , Alain Woda (5) , Serge Marchand (6) , Amandine Dubois (1, 7, 8) , Marie-Agnès Giroux-Metges (9, 2) , Fabrice Rannou (9, 2) , Laurent Misery (1) , Céline Bodéré (1, 2, 3)

1 LIEN - Laboratoire sur les interactions Epithéliums Neurones
2 CHU - BREST - Hôpital de la Cavale Blanche - CHRU Brest
3 UBO UFR Odontologie - Université de Bretagne Occidentale - UFR Odontologie
4 IFMK Brest - Institut de formation en masso-kinésithérapie
5 CROC - Centre de Recherche en Odontologie Clinique
6 UdeS - Université de Sherbrooke
7 LP3C - EA1285 - Laboratoire de Psychologie : Cognition, Comportement, Communication
8 UBO UFR LSH - Université de Bretagne Occidentale - UFR Lettres et sciences humaines
9 ORPHY (EA 4324) - Optimisation des régulations physiologiques

Introduction: The main symptom of fibromyalgia (FM) is diffuse pain. There is currently no aetiological treatment for FM. However, all pain associations and best practice guidelines strongly advocate the practice of aerobic physical activity to improve the symptoms of FM subjects. The mechanisms of dysfunctional pain are mostly central and related to stress axis dysfunction (autonomic nervous system and corticotropic axis). Our main objective is to assess the efficacy of a specific training programme on endogenous pain control mechanisms in female patients with FM. Further aims include rebalancing the autonomic neurovegetative system, improving quality of life and sleep quality, and reintegrating patients into society and work. Methods and analysis: 110 female patients with FM diagnosed on American College of Rheumatology 2010 criteria, aged 18-65 years and meeting inclusion conditions will be recruited and randomised into two groups (active and semiactive). The training programme will consist of three 45 min sessions per week of supervised, individualised physical activity over 2 years. Only the intensity of the exercises will differ between the two groups (moderate intensity vs low intensity).All outcome measures will be conducted at baseline (T0), after 6-9 months of training (T6-9) and after 24 months of training (T24). The primary endpoint will be an improvement of pain modulation (activation of diffuse noxious inhibitory control) evaluated by the stimulation test. The secondary endpoint will be relief of pain, anxiety, depression, stress, sleep disorders, pain impact on life quality, and improved heart rate, blood pressure and salivary cortisol. Ethics and dissemination: This study is approved by the Committee for the Protection of Persons West VI. The results will be published in specialised scientific journals and will be presented at scientific meetings on pain and/or physical activity. Trial registration number: NCT02486965; Pre-results.

Mots clés: rehabilitation medicine; pain management; fibromyalgia

Domaines: Santé publique et épidémiologie

Anais Le Fur Bonnabesse, Mathilde Cabon, Gildas L’heveder, Aurélie Kermarrec, Bertrand Quinio, et al.. Impact of a specific training programme on the neuromodulation of pain in female patient with fibromyalgia (DouFiSport): a 24-month, controlled, randomised, double-blind protocol. BMJ Open, 2019, 9 (1), pp.e023742. ⟨10.1136/bmjopen-2018-023742⟩. ⟨hal-02127792⟩