Netrin-1 feedforward mechanism promotes pancreatic cancer liver metastasis via hepatic stellate cell activation, retinoid, and ELF3 signaling

Crissy Dudgeon (1) , Anthony Casabianca (2) , Chris Harris (2) , Charline Ogier (3) , Mélanie Bellina (4) , Stephany Fiore (4) , Agnes Bernet (4, 5) , Benjamin Ducarouge (5) , David Goldschneider (5) , Xiaoyang Su (1) , Jason Pitarresi (6) , Aram Hezel (2) , Subhajyoti De (1) , Wade Narrow (2) , Fady Soliman (1) , Cory Shields (7) , Debora Barbosa Vendramini-Costa (3) , Orjola Prela (2) , Lan Wang (2) , Igor Astsaturov (3) , Patrick Mehlen (4) , Darren R Carpizo (2)

1 Rutgers cancer institute of New Jersey [Newark, NJ]
2 University of Rochester School of Medicine and Dentistry
3 Fox Chase Cancer Center
4 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
5 Netris Pharma
6 UMASS - University of Massachusetts System
7 University of Rochester [USA]

Highlights d Netrin-1 is upregulated in metastatic pancreatic cancer d Hepatic stellate cell-secreted retinoic acid upregulates Netrin-1 in the liver d Netrin-1 on extracellular vesicles preconditions the metastatic niche

Domaines: Cancer

Crissy Dudgeon, Anthony Casabianca, Chris Harris, Charline Ogier, Mélanie Bellina, et al.. Netrin-1 feedforward mechanism promotes pancreatic cancer liver metastasis via hepatic stellate cell activation, retinoid, and ELF3 signaling. Cell Reports, 2023, 42, ⟨10.1016/j.celrep.2023.113369⟩. ⟨hal-04382892⟩