Changing patterns of human migrations shaped the global population structure of Mycobacterium tuberculosis in France

Maxime Barbier (1) , Oana Dumitrescu (2, 3) , Catherine Pichat (3) , Gérard Carret (3) , Anne-Sophie Ronnaux-Baron (4) , Ghislaine Blasquez (4) , Christine Godin-Benhaim (5, 6) , Sandrine Boisset (7) , Anne Carricajo (8) , Véronique Jacomo (9) , Isabelle Fredenucci (3) , Michèle Pérouse De Montclos (3) , Charlotte Genestet (10) , Jean-Pierre Flandrois (11, 3) , Florence Ader (12, 13) , Philip Supply (14) , Gérard Lina (2, 3) , Thierry Wirth (1) , Jean-Philippe Rasigade (2, 1, 3)

1 ISYEB - Institut de Systématique, Evolution, Biodiversité
2 CIRI-StaPath - Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [CIRI]
3 IAI - Institut des Agents Infectieux [Lyon]
4 Comité Départemental d’Hygiène Sociale - CLAT69 [Lyon)
5 ARS - Agence régionale de santé Auvergne Rhône Alpes
6 ARS - Agence Régionale de la Santé
7 IBP - Institut de Biologie et de Pathologie [CHU Grenoble]
8 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
9 Biomnis Laboratory
10 CIRI - Centre International de Recherche en Infectiologie
11 PEGASE - Département PEGASE [LBBE]
12 CIRI-LegioPath - Pathogenèse des légionelles- Legionella pathogenesis [CIRI]
13 Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL]
14 CIIL - Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204

Mycobacterium tuberculosis (Mtb) exhibits a structured phylogeographic distribution worldwide linked with human migrations. We sought to infer how the interactions between distinct human populations shape the global population structure of Mtb on a regional scale. We applied the recently described timescaled haplotypic density (THD) technique on 638 minisatellite-based Mtb genotypes from French tuberculosis patients. THD with a long-term (200 y) timescale indicated that Mtb population in France had been mostly influenced by interactions with Eastern and Southern Europe and, to a lesser extent, Northern and Middle Africa, consistent with historical migrations favored by geographic proximity or commercial exchanges with former French colonies. Restricting the timescale to 20 y, THD identified a sustained influence of Northern Africa, but not Europe where tuberculosis incidence decreased sharply. Evolving interactions between human populations, thus, measurably influence the local population structure of Mtb. Relevant information on such interactions can be inferred using THD from Mtb genotypes.

Domaines: Bactériologie; Evolution [q-bio.PE]; Interactions entre organismes

Maxime Barbier, Oana Dumitrescu, Catherine Pichat, Gérard Carret, Anne-Sophie Ronnaux-Baron, et al.. Changing patterns of human migrations shaped the global population structure of Mycobacterium tuberculosis in France. Scientific Reports, 2018, 8 (1), pp.5855. ⟨10.1038/s41598-018-24034-6⟩. ⟨hal-01908989⟩