Antibacterial Zirconia Surfaces from Organocatalyzed Atom-Transfer Radical Polymerization

Nesrine Harfouche (1) , P Marie (2, 3) , Diana Dragoe (4) , Hung Le (5) , Pascal Thébault (5) , Christelle Bilot (6) , Arnaud Fouchet (6) , Jacques Rouden (1) , Jérôme Baudoux (1) , Bénédicte Lepoittevin (1)

1 LCMT - Laboratoire de chimie moléculaire et thioorganique
2 CIMAP - UMR 6252 - Centre de recherche sur les Ions, les MAtériaux et la Photonique
3 NIMPH - Nanomatériaux, Ions et Métamatériaux pour la Photonique
4 ICMMO - Institut de Chimie Moléculaire et des Matériaux d'Orsay
5 PBS - Polymères Biopolymères Surfaces
6 CRISMAT - Laboratoire de cristallographie et sciences des matériaux

Antibacterial coatings are becoming increasingly attractive for application in the field of biomaterials. In this framework, we developed polymer coating zirconia with antibacterial activity using the “grafting from” methodology. First, 1-(4-vinylbenzyl)-3-butylimidazolium chloride monomer was synthesized. Then, the surface modification of zirconia substrates was performed with this monomer via surface-initiated photo atom transfer radical polymerization for antibacterial activity. X-ray photoelectron spectroscopy, ellipsometry, static contact angle measurements, and an atomic force microscope were used to characterize the films for each step of the surface modification. The results revealed that cationic polymers could be successfully deposited on the zirconia surfaces, and the thickness of the grafted layer steadily increased with polymerization time. Finally, the antibacterial adhesion test was used to evaluate the antibacterial activity of the modified zirconia substrates, and we successfully showed the antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa strains.

Mots clés: Zirconia; cationic polymer; surface modification; atrp; xps; Antibacteial activity

Domaines: Chimie; Polymères

Nesrine Harfouche, P Marie, Diana Dragoe, Hung Le, Pascal Thébault, et al.. Antibacterial Zirconia Surfaces from Organocatalyzed Atom-Transfer Radical Polymerization. Materials, 2024, 17 (8), pp.1775. ⟨10.3390/ma17081775⟩. ⟨hal-04544266⟩